Uniform antibacterial cylindrical nanoparticles for enhancing the strength of nanocomposite hydrogels

Crystallization-driven self-assembly (CDSA) was employed for the preparation of monodisperse cationic cylindrical nanoparticles with controllable sizes, which were subsequently explored their effect on antibacterial activity and mechanical properties nanocomposite hydrogels. Poly(ɛ-caprolactone)-block-poly(methyl methacrylate)-block-poly[2-(tert-butylamino) ethyl methacrylate] (PCL-b-PMMA-b-PTA) triblock copolymers synthesized using combined ring-opening RAFT polymerizations, then self-assembled into polycationic micelles lengths by epitaxial growth. The cylinders exhibited intrinsic cell-type-dependent capabilities against gram-positive gram-negative bacteria under physiological conditions, without quaternization or loading any additional antibiotics. Furthermore, when anionic alginate hydrogel networks, response composite tunable enhanced up to 51%, suggesting that polymer fibers controlled are promising mimics fibrous structures in natural extracellular matrix support scaffolds. Overall, this fiber/hydrogel shows potential as an injectable biomaterial, possible application implant materials bacteriostatic agents bactericides various infections.